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Analytical Science & Technology (Bioprocess Data Integration)
Digitalising biomanufacturing - from cell-level mechanisms to industrial plants - for better bioprocesses
The Bioprocess Data Integration group creates computational and data-driven methods and frameworks to digitalise the process development for biomanufacturing processes. By developing and applying a variety of modelling approaches, we aim to better understand biological mechanisms across a wide spectrum of scales. Hence, our work accelerates decision-making and translation, enabling the faster, smarter, and cost-effective development of innovative biotherapeutics.
Focus Areas
- Computational metabolic modelling
- Natural Language Processing (NLP)
- Scientific software development
- Immune cell manufacturing modelling
- Process Modelling and Techno-Economic Analysis (TEA)
Our Capabilities
The Team
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Our Track Record
Significant Milestones
- Industry Translation, Media Design Spinoff & Licensing: Creation of an A*STAR Spinoff company, AuctuCel Pte Ltd
Featured Publications
- Sammueal Jun Kai Ong, Matthew Myint, Sean Chia, Chee Fan Tan, Yi Fan Hong, Meiyappan Lakshmanan, Ying Swan Ho, Thomas T. Wheeler, Xuezhi Bi, Ian Walsh and Kuin Tian Pang (2025) Health benefits of polysaccharides in red algae: a comprehensive review. Food Frontiers 1-26
- Ian Walsh †, Thimo Ruethers †, Sim Lyn Chiin, Gavin Teo, Shi Jie Tay, Corrine Wan, Kuin Tian Pang, Sean Chia, Andreas L. Lopata and Beiying Qiu (2025) Differentiation of Fish Species Based on O-Acetylated N-Glycan Fragments Using LC-IM-MS to Combat Seafood Adulteration. Applied Food Research 5(2): 101428
- Sammueal Ong Jun Kai, Matthew Myint, Chee Fan Tan, Yi Fan Hong, Meiyappan Lakshmanan, Ying Swan Ho, Thomas T. Wheeler, Xuezhi Bi, Ian Walsh, Sean Chia and Kuin Tian Pang (2025) Is green algae polysaccharide a 'green path' to health? Algal Research 91: 104268
- Hanzhang Zhou, Larry Sai Weng Loo, Francesca Yi Teng Ong, Xuanming Lou, Jiahao Wang, Matthew Khine Myint, Aaron Thong, Deborah Chwee San Seow, Mario Wibowo, Shengyong Ng, Yunbo Lv, Leng Gek Kwang, Rachel Z Bennie, Kuin Tian Pang, Renwick C J Dobson, Laura J Domigan, Yoganathan Kanagasundaram and Hanry Yu (2025) Cost-effective production of meaty aroma from porcine cells for hybrid cultivated meat. Food Chemistry 473: 142946
- Hoi Kong Meng, Kuin Tian Pang, Corrine Wan, Zi Ying Zheng, Qiu Beiying, Yuansheng Yang, Wei Zhang, Ying Swan Ho, Ian Walsh and Sean Chia (2024) Thermal and pH stress dictate distinct mechanisms of monoclonal antibody aggregation. International Journal of Biological Macromolecules 282: 136601
- Kuin Tian Pang, Yi Fan Hong, Fumi Shozui, Shunpei Furomitsu, Matthew Myint, Ying Swan Ho, Yaron R Silberberg, Ian Walsh and Meiyappan Lakshmanan (2024) Genome-scale modeling of CHO cells unravel the critical role of asparagine in cell culture feed media. Biotechnology Journal 19(11): e202400072
† Authors contributed equally to this work.
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