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There is provided a method for promoting stem cell chondrogenesis, comprising the step of culturing a population of stem cells on a plurality of imprints disposed on a substrate, the imprints being configured to selectively promote chondrogenesis of the stem cells.

A polymer waveguide for coupling with one or more light transmissible devices, a method of fabricating a polymer waveguide for coupling with one or more light transmissible devices, and a method of coupling a polymer waveguide with one or more light transmissible devices. The polymeric waveguide comprises a grating structure.

Phase contrast microscopy images are collected of a liquid sample containing one or more microscopic objects. The images are analyzed to track the motion of the microscopic objects within the liquid sample. Using the updated locations of the tracking objects, a controller can generate control signals for controlling the microscopy parameters, to ensure that the portion of the liquid sample which is imaged includes the tracking objects. The tracking objects may be cells or cell-spheres. Thus, the system can, for example, track cells and cell-spheres, to observe their growth, during a long time-lapse experiment.

According to embodiments of the present invention, a semiconductor photomultiplier device is provided. The semiconductor photomultiplier device includes a substrate having a front side and a back side, a common electrode of a first conductivity type adjacent to the back side, and a cell including an active region of a second conductivity type adjacent to the front side, and a contact region of the second conductivity type adjacent to the front side, the contact region being spaced apart from the active region by a separation region.

Cationic, anionic, and/or zwitterionic bis-urea compounds self-assemble by non-covalent interactions in aqueous solution to form high aspect ratio nanofibers. The nanofibers reversibly bind drugs by non-covalent interactions, forming drug compositions for exhibiting sustained release of the drug.

According to embodiments of the present invention, a resistive memory arrangement is provided. The resistive memory arrangement includes a nanowire, and a resistive memory cell including a resistive layer including a resistive changing material, wherein at least a section of the resistive layer is arranged covering at least a portion of a surface of the nanowire, and a conductive layer arranged on at least a part of the resistive layer. According to further embodiments of the present invention, a method of forming a resistive memory arrangement is also provided.

According to embodiments of the present invention, a waveguide structure is provided. The waveguide structure includes a silicon-on-insulator layer, and a semiconductor waveguide disposed on the silicon-on-insulator layer, wherein the semiconductor waveguide includes a tapering region.

A method for sensing, a photonic crystal fiber, a method for fabricating a photonic crystal fiber sensor, and a Surface Enhanced Raman Scattering (SERS) sensing apparatus. The method for sensing comprises the steps of providing a photonic crystal fiber comprising a hollow core and a plurality of cladding holes around the hollow core; providing Surface Enhanced Raman Scattering (SERS) active nanoparticles; and adapting the SERS active nanoparticles and/or the fiber for SERS sensing.

A microfluidic device and a microfluidic system are provided. The microfluidic device includes a support substrate; and at least one filter array arranged on the support substrate and configured so as to trap a single cell in contact with the support substrate within the at least one filter array when a sample including a plurality of cells flows into the microfluidic device from a direction substantially perpendicular to a plane of the support substrate and flows out in a direction substantially parallel to the plane of the support substrate.

15POWDER FEEDING NOZZLE, ASSEMBLY AND METHOD FOR LASER AIDED ADDITIVE MANUFACTURINGAn inner nozzle portion for a powder feeding nozzle is provided capable of being coaxially arranged within an outer nozzle portion of the powder feeding nozzle, the inner10 nozzle portion including: an upper section having a plurality of defined shapes on a surface thereof configured to manipulate a stream of powder flowing across said surface of the upper section; and a lower section having a substantially flat conical surface for forming a channel between said substantially flat conical surface and an inner surface of the outer nozzle portion when the inner nozzle portion is coupled to the outer nozzle15 portion, the inner nozzle portion being in communication with a powder inlet for receiving the stream of powder to flow across the surface of the upper section through the channel and towards a powder discharge outlet of the channel. There is also provided a powder feeding nozzle including the inner nozzle portion being coaxially arranged within the outer nozzle portion, an assembly and a method for laser aided additive manufacturing20 including the powder feeding nozzleFIG. 2