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Cai Shirong’s main research interest is in infant sleep as a modifiable target for health interventions and the risk factors that shape infant sleep.

Presented with the opportunities to access developmental cohorts strategically positions Cai to study infant sleep alongside subsequent developmental stage outcomes such as cognition, mood, behaviours, growth, adiposity and cardio-metabolic health. Aside from infant sleep, she also has a keen interest in multidisciplinary research, linking psychology and neuroscience with metabolic conditions such as gestational diabetes.

She won A*STAR IHDP's Emerging PI award in 2019, Best Poster award at the 8^th World Congress on Developmental Origins of Health and Disease (DOHaD) in 2013, and the Young Investigator Award (Clinical) at the University Obstetrics and Gynaecology Congress in 2012.

Cai received her PhD from the NUS Yong Loo Lin School of Medicine.


PUBLICATIONS

Evelyn Law is a clinician-scientist specialising in the area of developmental and behavioural paediatrics. In addition to her role as a principal investigator at A*STAR IHDP, she’s also an assistant professor in the Department of Paediatrics at NUS Yong Loo Lin School of Medicine, and a consultant in the Department of Paediatrics at Khoo Teck Puat-National University Children's Medical Institute, National University Hospital (NUH).

Law’s research interests centre on the life course of attention-deficit/hyperactivity disorder (ADHD) from preschool to adult years and the influences of family and child factors, including socioeconomic status (SES), parental psychopathology, and health on developmental outcomes of children. Her current studies and grants examine a prediction model of ADHD diagnostic stability in preschoolers and trajectories of executive functioning among children from different SES and family backgrounds in the GUSTO birth cohort study.

She received her Bachelor degree in Biological Sciences with cum laude and departmental honours from Northwestern University in 2002, and then pursued research in germ cell development at the Division of Reproductive, Stem Cell and Perinatal Biology at Stanford University School of Medicine before continuing her medical training. She completed residency in Paediatrics at the Harvard Medical School/Boston University School of Medicine joint programme in 2010, and completed subspecialty medical training in Developmental-Behavioural Paediatrics at Harvard Medical School/Boston Children’s Hospital. During her subspecialty training, she also completed the Clinical Effectiveness (Biostatistics and Epidemiology) Programme at the Harvard School of Public Health. 

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PUBLICATIONS

Lena Lim’s scientific work focuses on early-life stress – particularly the neural correlates of childhood maltreatment. She is interested in the neurobiological pathways between childhood trauma and the transition to psychiatric disorders and destructive behaviours, and how this may be moderated by genetic vulnerability. Her other research interests include self-harm and suicide in young people as well as childhood neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).

She obtained her PhD (Child and Adolescent Psychiatry) and postdoctoral training from the Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, U.K. She is also an Associate Fellow and Chartered Psychologist of the British Psychological Society (BPS), U.K.


PUBLICATIONS

In addition to his role at A*STAR IHDP, Huang Pei is also a visiting fellow at the National University of Singapore’s Multimodal Neuroimaging in Neuropsychiatric Disorders Laboratory. He spent a year at A*STAR’s �����Bioimaging Consortium before joining SICS.

Huang’s research spans two complementary domains within neuroimaging. The first focuses on developing and refining MRI analysis methods to more effectively leverage complex multimodal data and uncover patterns that are often overlooked by traditional approaches. The second involves applying these advance tools to investigate the developmental origins and neural profiles of mental health disorders, with an emphasis on childhood and adolescence.

On the methodological front, Huang works on approaches that move beyond region-by-region analyses toward global, network-level characterizations of brain organisation. His work incorporates whole-brain graph metrics, parametric feedback inhibition control (pFIC) models to estimate regional excitatory–inhibitory balance across the cortex, longitundal trajectory analyses and a full suite of established neuroimaging techniques including resting-state fMRI, diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS). Together, these methods enable a more integrative and mechanistic understanding of how large-scale networks operate and interact.

In his applied mental-health research, Huang examines how MRI can help delineate the neural signatures that underlie diverse mental health presentations, with the goal of identifying distinct subprofiles or dimensional phenotypes rather than relying solely on categorical diagnoses. His work aligns with the NIMH Research Domain Criteria (RDoC) framework, emphasizing transdiagnostic dimensions that map more directly onto brain circuits. Reflecting this direction, he was recently awarded the NMRC OF-YIRG to investigate dimensional approaches to mental health in children and adolescents, leveraging multimodal MRI to parse developmental trajectories and brain–behaviour relationships.

Huang obtained both his Bachelor of Science in Physics and PhD in Medical Physics from the University of Cambridge.

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PUBLICATIONS

Huang Yunying's research interests are focused on understanding how the brain evolves across the human lifespan and its capacity for reorganisation in response to experience, injury, and environmental factors. She is particularly interested in exploring how these processes unfold at different stages of life and how they can be harnessed for therapeutic interventions with multimodal imaging techniques. By combining methods such as MRI, EEG and NIRS, and MRI, she hopes to develop a more complementary and comprehensive understanding of brain dynamics.

Huang has studied brain plasticity during motor skill learning, investigating how cortical motor areas reorganise as skills transition from novel to automated in healthy participants. Using a combination of EEG and optical imaging (fNIRS & EROS), she has explored the dynamic changes in neural activity associated with motor learning. Additionally, she has worked with stroke patients, employing EEG and fMRI neurofeedback to induce targeted brain reorganisation as a potential adjunct to rehabilitation, aiming to enhance recovery and functional outcomes.

Her project on applying multimodal neurofeedback with stroke patients was selected for a presentation during the highlight session of the 25th European Stroke Conference in 2016 and also earned two student travel awards: One from Kellogg College (University of Oxford) in 2016 and another from the Real-Time Functional Imaging and Neurofeedback Conference in 2015.

Huang obtained her Bachelor degree in Psychology and Master's degree in Social Science (Research) at the National University of Singapore, and did her DPhil in Clinical Neurosciences at the University of Oxford.

Michelle Kee’s research focuses on antenatal maternal well-being, maternal childhood adversity and parenting styles.

Using data from two multi-ethnic, ongoing longitudinal cohorts in �����– one when mothers were recruited during mid-pregnancy stage (GUSTO) and the other involved women recruited during preconception phase (S-PRESTO) – she aims to understand how gene-by-parental-care (or “gene-by-environmental”) interactions predict neurodevelopmental and socio-emotional outcomes in the offspring.

The key projects she’s involved in look into understanding maternal well-being and parenting styles on a child's cognitive and socio-emotional outcomes; and studying how genetic profile scores of psychiatric disorders, traits and susceptibility associates with maternal parenting styles, well-being and a child's outcomes. She’s also leading the Mapping Antenatal Maternal Stress (MAMS) study, where she and her team aim to build a biologically informed prediction model of maternal well-being.

Kee obtained her Bachelor of Science from Nanyang Technological University and her PhD in Integrated Biology and Medicine from Duke-NUS Medical School.

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PUBLICATIONS

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Desiree Phua is a social psychologist who is interested in the effects of the social and digital environment on adolescent development and well-being. She is particularly interested in the social cognitive mechanisms that mediate the interplay of the environment and adolescents' identity.

Her work also focuses on the positive mental health or development of the young people that allows them to thrive or flourish beyond the absence of ill mental health symptoms. As an interdisciplinary researcher, her projects often utilise diverse methodologies from quantitative, qualitative, to experimental methods that span multiple disciplines. 

Phua obtained both her Bachelor of Arts in Psychology and PhD from the Nanyang Technological University.

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PUBLICATIONS

Wong Yi Sheng is a Scientist with the Translational Neurosciences domain at A*STAR IHDP. He previously held research fellow positions at the Nanyang Technological University's (NTU) School of Physical and Mathematical Sciences and National Institute of Education.

His research interests primarily lie in cognitive neuroscience, with a strong emphasis on neuroimaging methodologies like EEG and fMRI. Broadly, he investigates the link between resting-state functional connectivity and individual differences, and neurocognitive predictors of learning and educational outcomes.

During his PhD research, Wong proposed a novel theoretical framework conceptualising mind wandering as a form of task-set switching. He conducted multiple behavioural and EEG experiments to test this framework, advancing theoretical integration between attentional control and mind-wandering research.