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There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. The resulting delivery vehicles may be used to deliver an anti-cancer agent to a cell.

The invention relates to an apparatus (1) for culturing anchorage-dependent cells. The apparatus (1) comprises a housing (2) with an inlet (4) and an outlet (5), and a plurality of culture plates (6) removably stacked within the housing (2). The housing (2) has a circumferential wall (7), a base (8) and a top wall (9). The base (8) comprises the inlet (4) and the top wall (9) comprises the outlet (5). The circumferential wall (7) of the housing (2) defines a longitudinal axis thereof, as well as an inner cross section perpendicular to the longitudinal axis. Shape and dimensions of the inner cross section are essentially uniform along the longitudinal axis. The culture plates (6) are arranged at least essentially parallel to each other. Each plate (6) is mounted and sealed to the circumferential wall (7) of the housing (2). Plates (6) are arranged at a distance from each other. Each culture plate (6) has a through hole (14), so that inlet (4) and outlet (5) are in fluid communication. Each through hole (14) is positioned at an outer end of the respective culture plate (6), proximate the circumferential wall (7). Through holes (14) of adjacent culture plates (6) are distally positioned in the plane of the inner cross section of the housing (2).

A guide wire arrangement is provided. The guide wire arrangement includes an elongate coil element having two opposing ends; a force transmitting element arranged at one of the two opposing ends of the coil element; a sensor assembly arranged in the coil element at a predefined distance away from the force transmitting element; and a core wire extending from the force transmitting element to the sensor element through the coil element; wherein the coil element is configured to allow the core wire to be moveable relative to the sensor assembly and the sensor assembly is configured to detect movement of the core wire relative to the sensor assembly upon force impact on the force transmitting element.

According to embodiments of the present invention, a transceiver device is provided. The transceiver device includes a receiver configured to wirelessly receive a signal having a master-remote frequency from a communication device; a frequency converter configured to convert the master-remote frequency of the received signal to a remote-terminal frequency; and a transmitter configured to transmit the converted signal having the remote-terminal frequency to a communication terminal. Other embodiments provide a transceiver device including a receiver configured to receive a signal having a remote-terminal frequency from a communication terminal; a frequency converter configured to convert the remote-terminal frequency of the received signal to a master-remote frequency; and a transmitter configured to wirelessly transmit the converted signal having the master-remote frequency to a communication device. According to further embodiments of the present invention, a method of transmitting a converted signal and a method of receiving a signal are also provided.

We describe a method of expressing a recombinant protein comprising mannose-terminated N-glycans from a host cell, the method comprising: (a) introducing a nucleic acid encoding a recombinant protein into a Chinese Hamster Ovary (CHO) cell comprising a mutation in the GnT 1 gene (GenBank Accession Number AF343963) leading to loss of GnT 1 function; and (c) expressing the recombinant protein from the host cell, in which the expressed recombinant protein comprises a mannose-terminated glycan structure, and in which the method does not include a step of introducing functional GnT-I into the host cell. The method may be used for producing recombinant glucocerebrosidase with a mannose-terminated glycan structure, suitable for treatment or prevention of Gaucher's Disease.

The invention relates to a nucleic acid molecule comprising a functional promoter of a herpesvirus, a functional enhancer of a herpesvirus, and one or more internal elements of the CpG island of the aprt (adenine phosphoribosyl transferase) gene and/or a functional variant thereof. A method of producing a desired polypeptide using the nucleic acid molecule, a vector and a host cell containing the nucleic acid molecule are also disclosed.

The invention relates to a layer arrangement and a wafer level package comprising the layer arrangement, and in particular, the layer arrangement comprises a getter layer and further comprises a sacrificial layer. The wafer level package may be used in microelectromechanical systems (MEMS) packaging at a vacuum level of about 10 mTorr or less such as close to 1 mTorr (i.e. MEMS vacuum packaging).

A power transfer device is provided. The power transfer device includes a circuit arrangement including a primary side having a primary coil; a secondary side having a secondary coil inductively coupled to the primary coil and a load transformation unit; wherein the load transformation unit includes an inductor and a capacitor; wherein the secondary coil, the inductor and the capacitor respectively includes a first terminal and a second terminal; wherein the first terminal of the secondary coil is coupled to the first terminal of the capacitor, the second terminal of the capacitor is coupled to the first terminal of the inductor, and the second terminal of the inductor is coupled to the second terminal of the secondary coil.

A method for plasmonic structure manufacture and for protecting a plasmonic nanostructure during annealing is provided. The method includes: lithographically forming a plasmonic nanostructure on a substrate; encapsulating the plasmonic nanostructure in high temperature resistant material; annealing the plasmonic nanostructure; and removing the high temperature resistant material to reveal the annealed plasmonic nanostructure.

Methods and systems are proposed for transmitting data from a source (110) to a destination (130) via a relay station (120) having multiple antennae (122, 124). The relay station (120) receives from the source a message containing the data and a first cyclic prefix. It does this using each of its antennae (122, 124), so producing multiple respective received signals. In certain embodiments, the relay station (120) removes the first cyclic prefix from the received signals, replacing it with a new one. In other embodiments, the relay station (120) removes only a portion of the first cyclic prefix. In either case, the relay station (120) may apply space-time coding to generate second signals, which it transmits to the destination (130), which extracts the data. Methods are also proposed for estimating parameters of the channel, to enable the destination (130) to decode the data.